Abstract
Serum concentrations of anticonvulsants were determined in 89 cases of epileptic patients, 78 phenobarbital specimen, 19 phenytoin specimen, 21 carbamazepine specimen. Sixty percent of the cases on phenobarbital and 14% of those on carbamazepine had therapeutic concentration.No cases receiving phenytoin achieved the therapeutic concentration of 10-20μg/ml.Furthermore, we found that serum concentrations of phenytoin were influenced by drug preparations.-especially by the particle size.Determination of serum concentration must be done in every patient with epilepsy because of differences in individual physiological factors as well as in the particle of drugs.
