Thyrotropin-releasing Hormone and Auditory Brain Stem Response

Abstract

The effect of intravenous thyrotropin-releasing hormone (TRH) injection on auditory brain stem response (ABR) was studied in ten children aged one month to ten years with various ABR abnormalities resulting from various neurological disorders. ABR was studied before and after an intravenous injection of 10μg/kg of TRH, for 40min at 4min intervals. Two patients showed post-TRH changes in ABR. A 10-year-old girl with absent waves III through V due to spinocerebellar degeneration showed temporary appearance of wave III starting from 5 min after the TRH injection and lasting for 25 min. A 6-year-old girl with an attenuated wave V accompanying pontine glioma showed an apparently increased amplitude of wave V from 5 to 45 min after the TRH injection.