A full term female infant was born to a healthy woman and was found to have severe microcephaly at birth. CT and renal arteriography showed lissencephaly with cystic dilatation of the posterior horn of the lateral ventricle and hypoplasia of the left kidney. Laboratory examinations disclosed remarkable thrombocytosis.
Since this infant was a product of a twin pregnancy with a stillborn macerated fetus, various abnormal manifestations including lissencephaly were considered to be caused by multiple intravascular coagulation.