Hypoxic-Ischemic Encephalopathy in Mice

II. Long-term Prognosis of Partially Asphyxiated Mouse

Abstract

Long-term prognosis of the mice exposed to 5% O2 for 8 hours in the neonatal period was investigated. The mortaliy rate increased in proportion to the extent of intracerebral hemorrhage in the neonatal period. The mice with extensive intracerebral hemorrhage showed marked growth failure and the weight of the cerebrum examined at 90 days was significantly reduced as compared with that in controls. The brains of those mice were microcephalic, and some of them exhibited porencephaly or multicystic encephalomalacia.