The Effect of Early Malnutrition and Subsequent Rehabilitation on Brain Development
II. Golgi-Cox Study
1985 Volume 17 Issue 6 Pages 548-557
Details
1985 Volume 17 Issue 6 Pages 548-557
This study was undertaken to investigate the effects of early malnutrition and subsequent rehabilitation on dendritic development of the mouse cerebral cortex with the quantitative Golgi-Cox method.
At the 60 days of life the number of dendrite crossings of pyramidal cells was reduced in M1-20 group (mice nursed in litters of 18 from day 1 to 20). Dendritic development in M1-10 and M11-20 groups was better than in M1-20, but it was still insufficient. While the dendritic development in M1-5 group was almostthe same as that in controls, dendritic development in M8-12 group was not sufficient.
The number of spines on apical dendrites of the pyramidal cells up to 75μm was reduced in M1-20 group at 20 days but recovered to normal at 60 days of life.
