Abstract
We investigated clinical and electroencephalographic data on 12 children with agenesis of corpus callosum. Seven patients had associated malformations of the central nervous system, including microcephalus, hypoplasia of cerebellum, and arachnoid cyst. Nine patients had extraneural anomalies, including unilateral microphthalmia, blephalophimosis, malformed auricles, low set ear, clenched fingers, nail hypoplasia, PDA, PS, and hypogonadism. Eleven patients had psychomotor retardation, D. Q. or I. Q. below 50 in 10 patients. Eight patients had epilepsy; generalized tonic-clonic seizures in 7 and focal motor seizure in one. EEG showed asymmetry in the basic activity or the background activity in 8 patients. Asymmetry of humps, spindles, and K-complexes was also noticed in 5, 9, and 2 cases, respectively. Five patients had asynchronous sleep spindles.
