Abstract
The peripheral nerve inpthe clipped tail of twitcher mouse was investigated ultrastructurally. Numerous electron angulated inclusions were observed within the cytoplasm of Schwann cellsin twitcher mice 28 days after birth. Tubular structures were observed within the lysosomes of Schwann cells in 4-day-old homozygotes. Furthermore, another unique structure which consisted of low dense crystalline interiors and high dense wall was found at 14 days. It was concluded that these structures were gradually transformed into typical inclusions at 28 days. These findings suggest that the peripheral nerve in twitcher mice was involved after birth, and early morphological changes of peripheral nerve in the. clipped tail can be used for the morphological diagnosis andaluation of treatment in affected mice.
