Neuronal Migration Disorders-Pathogenesis and Clinical Manifestations: Introductory Remarks

Abstract

Cortical dysplasias caused by the destruction of neuron production and migration have been recognized as relatively common neuropathological findings among the children with intractable epilepsy and mental and/or physical handicaps.
Together with various environmental factors, an increasing number of gene abnormalities have recently been identified as a cause of cortical dysplasias. However, the processes from the gene abnormality to the development of cortical dysgenesis remain unknown.
In this symposium, the pathology, pathogenesis and MRI manifestation of neuronal migration disorders as well as intimate correlation with intractable epilepsy and neurosurgical treatment for this disorder, were reviewed by six experts.