Pathological Spectrum of Neuronal Migration Disorder

Abstract

A variety of brain malformative lesions, resulting mainly from abnormalities in neuronal migration, have been recently highlighted with increasing knowledge on surgical pathology of intractable epilepsy. In this article, a wide spectrum of pathology in and around the neuronal migration period are reviewed. Morphological changes of lissencephalies, polymicrogyria, microdysgenesis and focal cortical dysplasia were described, as well as some problems in the classification of malformative brains.