Abstract
Seven cases of “moyamoya” disease were studied with regard to sex, age of onset, family and past history, clinical signs and symptoms, carotid angiograms and EEG. A boy was followed up for 6 years with repeated carotid angiography and EEG.
The disease appeared before 5 years of age in most cases. Successive carotid angiograms showed progressive cerebral vascular changes in a case. This fact suggests that congenital vascular abnormalities in the brain may have been aggravated by postnatal factors.
Prolonged slow wave formation in EEG after hyperventilation were of diagnostic value in this disease.
Five cases were diagnosed at the stage 3 of cartotid angiographic changes (Suzuki's classification). Clinical signs and symptoms got worse at the stages 5 and 6. The severity of clinical symptoms seemed to be related to the cerebral blood flow and the extent of the angiographic changes.
