Salivary Duct Carcinoma: Report of a case, immunohistochemical studies and a survey of Japanese cases

Abstract

Salivary duct carcinoma (SDC) is an extremely rare neoplasm which occurs in the salivary gland. We report a case of SDC arising from the parotid gland in an 82-year-old Japanese male. We examined the immunohistochemical studies and surveyed the Japanese cases. We excluded cases which were diagnosed on the basis of the previous classification. The patient underwent a radical parotidectomy. Histopathologically, the tumor exhibited comedo-carcinoma, with infiltrative desmoplasmic and cribriform patterns, and a neural invasion. Immunohistochemical studies demonstrated an SDC which consisted of ductal cells without any participation of myoepithelial cells. We confirmed 24 Japanese cases of SDC, including the present case, by the current WHO classification.