Behavioral Comparison of Oral Squamous Cell Carcinoma between Original and Metastatic Lymph Node Lesions

Masataka Uehara; Tsugio Inokuchi; Hisazumi Ikeda; Joji Sekine; Takayoshi Tobita; Seigo Ohba; Yuji Mizoguchi; Mihoko Nonaka; Akihiko Fujisawa

doi:10.3353/omp.10.73

Original

Behavioral Comparison of Oral Squamous Cell Carcinoma between Original and Metastatic Lymph Node Lesions

Masataka Uehara, Tsugio Inokuchi, Hisazumi Ikeda, Joji Sekine, Takayoshi Tobita, Seigo Ohba, Yuji Mizoguchi, Mihoko Nonaka, Akihiko Fujisawa

Author information

Masataka Uehara
Division of Oral and Maxillofacial Surgical Reconstruction and Functional Restoration, Department of Developmental and Reconstructive Medicine, Graduate School of Biomedical Sciences, Nagasaki University
Tsugio Inokuchi
Division of Oral and Maxillofacial Surgical Reconstruction and Functional Restoration, Department of Developmental and Reconstructive Medicine, Graduate School of Biomedical Sciences, Nagasaki University
Hisazumi Ikeda
Division of Oral and Maxillofacial Surgical Reconstruction and Functional Restoration, Department of Developmental and Reconstructive Medicine, Graduate School of Biomedical Sciences, Nagasaki University
Joji Sekine
Division of Oral and Maxillofacial Surgical Reconstruction and Functional Restoration, Department of Developmental and Reconstructive Medicine, Graduate School of Biomedical Sciences, Nagasaki University
Takayoshi Tobita
Division of Oral and Maxillofacial Surgical Reconstruction and Functional Restoration, Department of Developmental and Reconstructive Medicine, Graduate School of Biomedical Sciences, Nagasaki University
Seigo Ohba
Division of Oral and Maxillofacial Surgical Reconstruction and Functional Restoration, Department of Developmental and Reconstructive Medicine, Graduate School of Biomedical Sciences, Nagasaki University
Yuji Mizoguchi
Division of Oral and Maxillofacial Surgical Reconstruction and Functional Restoration, Department of Developmental and Reconstructive Medicine, Graduate School of Biomedical Sciences, Nagasaki University
Mihoko Nonaka
Division of Oral and Maxillofacial Surgical Reconstruction and Functional Restoration, Department of Developmental and Reconstructive Medicine, Graduate School of Biomedical Sciences, Nagasaki University
Akihiko Fujisawa
Division of Oral and Maxillofacial Surgical Reconstruction and Functional Restoration, Department of Developmental and Reconstructive Medicine, Graduate School of Biomedical Sciences, Nagasaki University

Keywords: oral squamous cell carcinoma, original lesion, metastatic lymph node lesion, vascular endothelial growth factor, proliferating cell nuclear antigen

JOURNAL FREE ACCESS

2005 Volume 10 Issue 2 Pages 73-76

DOI https://doi.org/10.3353/omp.10.73

Details

Abstract

Immunohistochemical expression of vascular endothelial growth factor (VEGF) and proliferating cell nuclear antigen (PCNA) in oral squamous cell carcinomas (OSCCs) was investigated comparatively between the original and the metastatic lymph node lesions of the same tumor. Tissue samples of both the original and regional lymph node lesions were obtained from 11 patients who did not receive preoperative radiotherapy. The percentage of VEGF immunopositive area (PVIA) in the tumor was determined through computer image analysis. Proliferative activity of tumor cells was assessed in terms of the labeling index (LI) of PCNA. PCNA LI showed no correlation between the original and metastatic tumors, whereas the PVIA appeared to be similar between the original and regional lymph node lesions. These results suggest that immunohistochemical expression of VEGF in the original tumor shows the characteristic behavior of a metastatic tumor, thus providing therapeutic information.

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