A case of Ameloblastic Fibro-Odontoma with Melanin Pigment in Dentin of Prominent Odontoma Components

Abstract

An unusual case of pigmented ameloblastic fibro-odontoma with prominent odontoma components in a 7-year-old Japanese boy is reported. In addition to the characteristic histopathologic features of ameloblastic fibro-odontoma, deposition of melanin pigments was found in the ameloblastic cells, mesenchymal cells resembling the dental papilla and calcified tissue including mature dentin. The pigments were stained positively with Fontana-Masson, and the pigment-laden cells in mature dentin were positive for HMB-45 by immunohistochemical staining. Such findings have not been described so far in any previously reported cases.