Intraneural perineurioma of the tongue: report of a case and review of the literature

Abstract

An intraneural perineurioma arising in the tongue of a 34-year-old woman is presented. Histologically, the tumor was composed of numerous pseudo-onion bulb structures, formed by whorled proliferation of spindle cells around axons. Immunohistochemically, the spindle cells were positive for epithelial membrane antigen (EMA) but negative for S-100 protein, indicating that the tumors cells were derived from perineurial cells.