Abstract
A case of acanthomatous ameloblastoma with melanin pigmentation occurring in the maxilla of a 27-year-old Japanese woman is reported. The microscopic examination of the biopsy and excision specimens of the tumor revealed proliferating ameloblastic tumor cells with a network of anastomosing strands. Within some epithelial strands, discrete foci of squamous metaplasia progressing to keratin pearl formation and dystrophic calcification were observed. Dark brown melanin granules were scattered in proliferating tumor nests and stromal connective tissue.