Abstract
A rare case of desmoplastic ameloblastoma is presented with an immunohistochemical study of epithelial cell markers. A 42-year-old Japanese woman was admitted with a complaint of painless swelling in the anterior mandible. Radiological examination revealed an ill-defined lesion with a mixed radiolucent-radiopaque appearance. Tumor extirpation was performed, and no sign of recurrence has been confirmed. Histological examination exhibited proliferative epithelial islands surrounded by extensive dense fibrous connective tissue stroma. Most of the tumor cells lacked ameloblastic cellular polarization. The tumor cells showed positive immunoreactivities for anti-cytokeratin 8, 13 and 19, filaggrin and ameloblastoma antibodies, retaining the odontogenic epithelial characteristics.
