Abstract
During our routine examination for surgical pathology of oral neoplasms, we found a case of basal cell adenoma with microcalcifications in tumoral stroma . Histopathology showed a tumor mass, covered with a thin fibrous connective tissue, and composed of cuboidal and/or columnar cells with round to ovoid nuclei. In parts of the intercellular stroma, numerous von Kossa's positive small granules were found. Under scanning electron microscopic observation, many small round granules in the stromal tissue were recognized. EPMA revealed that the granules consisted mainly of calcium and phosphorus. Immunohistochemistry showed the expression of osteopontin in the cytoplasm of neoplastic cells. Therefore, we thought that the osteopontin might have some role in the stromal microcalcification in this case of basal cell adenoma.
