Abstract
The purpose of this article is to review recent experimental studies on oral tumors including the odontogenic tumors which were produced by a combination of carcinogen application with physical wounding. Many experimental studies on carcinogenesis have suggested that physical wounding or mechanical stimulation is sufficient to promote the growth of both benign and malignant neoplasms. Furthermore, a novel genome of papillomavirus was identified in these dysplastic and cancer lesions produced in hamsters . The interactions between chemical carcinogens, physical irritations and papillomavirus in carcinogenesis are also described.
