Inflammatory Pseudotumor and Related Lesions of the Oral and Maxillofacial Region: A critical reappraisal based on recent information

Abstract

The term pseudotumor is used for a broad category of tumorous proliferations that are considered to be reactive rather than neoplastic and that can simulate malignant tumors. Presently, its nosologic position in the pathological diagnosis is still largely elusive and disputable. In this report, we present a comprehensive review of so-called inflammatory pseudotumor and its related lesions in the oral and maxillofacial region with different diagnostic considerations. The spectrum of these pseudotumors undoubtedly encompasses a diverse group of inflammatory fibrohistiocytic / myofibroblastic lesions with different causes, pathogeneses, and clinical and pathological implications.