Central Odontogenic Granular Cell Tumor: Report of a case and immunohistochemical studies

Abstract

Central odontogenic granular cell tumor (COGCT) is a rare neoplasm, and although there have been previous immunohistochemical analysis and electron microscopic studies reported in the literature, the histogenesis of the granular cells has not been elucidated. We performed immunohistochemical analysis of a COGCT, in which the granular cells stained positively for α-1-antichymotrypsin and weakly positively for vimentin. However, since all other stains, including s-100 protein, desmin, neurofilament, α-smoothmuscle actin, CD 68, and MAC 387, were negative, our immunohistochemical findings suggested that the granular cells were derived from histiocytic cells.