Abstract
We report here a rare case of primary B-cell lymphoma in the submandibular lymph node that spread to the deep cervical lymph nodes of a 55-year-old man. The lymphoma was accompanied by a chronic sialadenitis of the submandibular gland with a cluster of lymphocytes and exhibited a typical pattern of follicular lymphoma. Immunohistochemical and flow cytometric analysis showed the presence of CD10, CD19 and bcl-2 on lymphoid cells in the follicles, which confirmed that this nodal lesion was follicular lymphoma. The manner of spreading of the lymphoma indicated that the primary lesion originated in the submandibular region. In spite of a diagnosis of Grade 1, the lesion had spread to the deep cervical lymph nodes. A possible relationship between sialadenitis and the initiation of lymphoma was not detected by the present examinations.
