Abstract
Experimental studies were performed on the role of the central nervous system in thermoregulatory function from the standpoint of fever reaction. At first observation was made on the changes of the fever reaction following heat puncture caused by the modification of various regulatory systems. Next the thermoregulatory role of the amygdaloid nucleus in the cerebral limbic system was investigated by means of heat puncture. In addition, the temperature and electroencephalogram of the hypothalamus and amygdaloid nucleus after the administration of pyrogen, adrenaline, and noradrenaline were observed in the course of time. As a result the following findings were obtained.
1) In the case of heat puncture immediately after section of the bilateral splanchnic nerves, the reaction of body temperature rise was maintained comparatively well, but the duration of it was shortened, presenting an evidently different course compared with the normal case. However, one week after the operation the change of body temperature was almost the same as in the normal case.
2) The rise of body temperature following heat puncture was not observed after pretreatment with chlorpromazine.
3) The body temperature rise following heat puncture was not observed 24 hours after the bilateral adrenalectomy, however, administration of cortisone restored body temperature similar to that of the normal case.
4) In liver disorder caused by carbon tetrachloride, heat puncture produced body temperature rise in cases to which small amount of carbon tetrachloride was administered, but did not in cases to which a greater amount was administered.
5) Many cases manifested a fall of body temperature immediately after the puncture at the lateral amygdaloid nucleus, resulting in a gradual rise of body temperature.
6) In many cases the puncture at the anterior amygdaloid nucleus produced a slight rise of body temperature.
7) In many cases the puncture at the medial amygdaloid nucleus produced a slight rise of body temperature.
8) The brain temperature change in various portions, anterior and posterior hypothalamus and amygdaloid nucleus by the administration of pyrogen (T. T. G.), adrenalin and noradrenalin showed a slight difference in the grade of change by its location. But the direct relationship between these local temperatures and their electroencephalograms had not been recognized.
9) The electroencephalogram of the anterior and posterior hypothalamus and amygdaloid nucleus in fever by administration of pyrogen (T. T. G.) showed, that high-frequency low-voltage waves became dominant 30sec. after injection, and the tendency kept on 10-15min., and thereafter restored gradually to the level of pre-administration. But in the temperature rising period, and in its previous period the tendency of high-frequency low voltage waves was observed again periodically and in the body temperature descending period a tendency towards slow waves was observed.
10) During the period from immediately to 5-7 minutes after the administration of adrenaline in a small dose (0.005mg/kg) a marked high-frequency low-voltage reaction was observed in the electroencephalogram of the hypothalamus and amygdaloid nucleus.
11) Administration of adrenaline of a medium dose (0.1mg/kg) gave rise to a marked rise of body temperature. The electroencephalogram of the hypothalamus and amygdaloid nucleus showed high frequency during the period from immediately to 3 minutes after the administration, recovered gradually to the normal activity level, and manifested a tendency to high frequency again at the hyperthermic stage.
12) Administration of adrenalin in a large dose (0.5mg/kg) gave a slight fall of body temperature, and E. E. G. of hypothalamus and amygdaloid nucleus showed a tendency towards low frequequency high voltage, slow waves.
13) Following the administration of noradrenaline almost a similar tendency as in the case of adrenaline was observed, although in a mediu
