Abstract
Improving the mechanical switch converting direct current amplifier, the author made the particularly high sensitive high speed recording thermoelectric thermometer suitable to perform the investigation in the field of research on the body temperature regulation, especially on response of its mechanism, such as a low level information recorded in the form of small wave of temperature that operated by the acting fine tissue construction of the body.
Utilizing this instrument, the author made a study of the wave components of the fluctuation in the temperature recorded from the various parts of the body, and the fluctuation on the differential thermograms between them. This experiment was done by rabbits in various conditions, such as being normal and healthy, being given several drugs, or being affected by fever.
1. Several series of waves are observed in the every record taken from various parts of the body (skin, subcutan tissue, vein, muscle, liver, rectum, hypothalamus, etc.) indicating their inherrent property in them. Most of them belonged to the series whose frequency is approximately 3-0.5r.p.m. and also the slower ones are observed, which was superposed frequently on the former ones.
2. As the result of injection of adrenaline, the frequency of the wave was increased, and its amplitude was decreased, and sometimes the wave had a tendency to disappear, but about 20 minutes later, it appeared again.
Injection of noradrenaline showed the same tendency as above. However, chlorpromazine indicated the opposite tendency, that is, the frequency was decreased, amplitude also decreased and pulsewide enlarged. A large dose of chlorpromazine caused the wave disappear.
Injection of atropin caused only slight change in this wave.
3. Similar effect with that of adrenaline was observed on T. T. G. (which is polysaccharide fraction extracted from pseudomonus fluorescence).
4. There were remarkable fluctuations in the records of the earlobe venous blood temperature.
Differential thermogram between venous blood and its irrigated tissue of the earlobe indicated that the venous blood was warmer than its irrigated tissue, and the existence of the similar fluctuation described above was shown. These wave forms were complicated, but it is very interesting to analyse this changing mechanism or controlling process.
5. Effect of adrenaline, noradrenaline or chlorpromazine on differential thermogram between the earlobe and the rectum was measured, and as the result the character of stepwise phase was noticed there.
6. Result of injection of adrenaline, after giving a large dose of chlorpromazine, showed no effect on the temperature difference between the earlobe and rectum, while injection of either noradrenaline or T. T. G. indicated clear but slight increase of the temperature difference.
7. In every differential thermogram between the liver and the rectum, temperature of liver was somewhat higher than that of rectum, and difference between them was increased when shivering occurred.
8. In comparison with the adrenal arterial blood, the reflux venous blood showed higher temperature, and T. T. G. increased this temperature difference in the earlier stage of the fever reaction.
In these experimental results, the author indicated several valuable utilization of this new instrument. From results described above, the author concluded the existence of the several time series which was closely correlated with the temperature regulation of the body. It is suggested that the nature of this wave may be some circulatory changes correlated with arteriovenous anastomoses and concerning regulation of them, symathetic adrenal control must be postulated.
