Human Individual Variability and Clinical Medicine

Masuyama's rule and its usefulness

Abstract

Prof. Motosaburo Masuyama has detailedly investigated the statistical distribution of more than 300 kinds of human biological traits, such as biochemical substances in blood. In his study, he found several empirical laws with respect to CV (coefficient of variation) of these traits, and proposed the two rules of human individual variability. The one was CV of fundamental blood components were less than 0.3, and another was the CV of these components did not differ by sex, race and age. In this paper, we first introduced his study. Second, we discussed the usefulness of his rules in the determination of initial dosis for patients with allergy. In addition, we tested the validity of his rules by using large size data obtained by the country-wide health check. We concluded that Masuyama's rules could apply many types of normal blood components of human being and be useful for designingg drug therapy, and for arranging clinical data. Since precise investigation performed by us showed that there are definite difference of CV between male and female, young and old, in many blood components, further study is needed.