Abstract
Platelets are the blood constituents which contain three types of granules, i. e., alpha granule, dense granule, and lysosomal granule. Each granule contains various biophysiological substances such as growth factors, cytokines, lipid mediators, etc. Platelets have been conventionally focused as trigger of inflammatory response and injury in the liver. However, in recent years, some studies uncovered that platelets have strong effects on promoting liver regeneration, anti-fibrosis, and antiapoptosis. This review presents experimental and clinical evidences of platelets in accelerating liver regeneration, anti-fibrosis, and anti-apoptosis and their mechanisms.
