Abstract
Donor shortage has been an unresolved problem in clinical transplantation. It is difficult to enlarge donor pool to the expanded criteria donor(ECD)by simple cold storage, due to the severe ischemia and reperfusion injury (IRI). Resuscitation of the susceptible grafts by extracorporeal perfusion has been studied, but there has been no gold standard yet. In this review, we summarized the efficacy of novel medical gases, hydrogen and helium, for the use as an antioxidant and anti-inflammatory agents. Since hydrogen gas alone could not improve ATP content, cytoskeletal integrity, homeostasis of cytosolic ions including Na＋, K＋, and Ca2＋, possiblesupplemental actions of heavy water were briefly described.
