Renal transplant immunosuppressive protocol with the aiming to establish a tailor-made therapy

Abstract

Short-term outcome of renal transplantation has dramatically improved due to advance in immunosuppressive agents. However effective treatments for chronic renal graft injury have not been established, and long-term outcome remained unsatisfactory. Transplanted kidney toxicity of side-effect of calcineurin inhibitors, and antibody-mediated rejection by anti-HLA antibodies are major factors hindering the long-term graft survival. To overcome chronic renal graft injury, we currently underway to establish tailor-made immunosuppressive therapy in renal transplantation, by grouping renal transplant recipients with immunological and non-immunological risk factors. Here we report our protocol and short-term results.