Abstract
Successful organ transplantation has been performed in parallel with the development of several immunosuppressive drugs. It is also important to carry out personalized immunosuppressive therapy to improve clinical outcome of organ transplantation. Clinical-pharmacological approaches have given many valuable insights into effective and safe drug use in organ transplantations. Here we summarize our clinical approaches concerning the personalized immunosuppressive therapy in renal transplantation by utilizing the data for individual peripheral-lymphocyte sensitivity to the immunosuppressive drugs. We also introduce, in this review, our pharmaceutical approach to improve organ preservation efficacy of the standard UW solution by adding new drugs or components to the solution.
