Abstract
We have previously reported that the differentiation of xeno-carbohydrate antigen-reactive B-1b cells is resistant to the effect of calcineurin inhibitors. Recent reports have indicated that the intrinsic B-cell MyD88 signaling plays an important role in T cell-independent antibody responses and in differentiation of antibody-secreting cells. In this study, we demonstrated that blocking TLR-MyD88 signaling enhanced the effect of calcineurin inhibitors on B-1b cells, both in vitro and in vivo. Therefore, TLR-MyD88 signaling can be a therapeutic target in managing the xeno-carbohydrate antigen-reactive B cell response.
