境界グラフトの健常性維持と機能再生を目指した移植肝臓器保存戦略～京都大学の取り組み～

秦 浩一郎; 岡村 裕輔; 玉木 一路; 後藤 徹; Nigmet Yermek; 日下部 治郎; 吉川 潤一; 田嶋 哲也; 稲本 道; 久保田 豊成; 平尾 浩史; 影山 詔一; 田中 宏和; 上本 伸二

doi:10.11378/organbio.24.181

Organ Preservation towards Functional Restoration and Maintenance of Extended-Criteria Donor Livers; Our Recent Strategies in Kyoto University

Koichiro Hata, Yusuke Okamura, Ichiro Tamaki, Toru Goto, Nigmet Yermek, Jiro Kusakabe, Junichi Yoshikawa, Tetsuya Tajima, Osamu Inamoto, Toyonari Kubota, Hirofumi Hirao, Shoichi Kageyama, Hirokazu Tanaka, Shinji Uemoto

Author information

Koichiro Hata
Department of Surgery, Division of Hepato-Biliary-Pancreatic Surgery and Transplantation, Kyoto University Graduate School of Medicine
Yusuke Okamura
Department of Surgery, Division of Hepato-Biliary-Pancreatic Surgery and Transplantation, Kyoto University Graduate School of Medicine
Ichiro Tamaki
Department of Surgery, Division of Hepato-Biliary-Pancreatic Surgery and Transplantation, Kyoto University Graduate School of Medicine
Toru Goto
Department of Surgery, Division of Hepato-Biliary-Pancreatic Surgery and Transplantation, Kyoto University Graduate School of Medicine
Nigmet Yermek
Department of Surgery, Division of Hepato-Biliary-Pancreatic Surgery and Transplantation, Kyoto University Graduate School of Medicine
Jiro Kusakabe
Department of Surgery, Division of Hepato-Biliary-Pancreatic Surgery and Transplantation, Kyoto University Graduate School of Medicine
Junichi Yoshikawa
Department of Surgery, Division of Hepato-Biliary-Pancreatic Surgery and Transplantation, Kyoto University Graduate School of Medicine
Tetsuya Tajima
Department of Surgery, Division of Hepato-Biliary-Pancreatic Surgery and Transplantation, Kyoto University Graduate School of Medicine
Osamu Inamoto
Department of Surgery, Division of Hepato-Biliary-Pancreatic Surgery and Transplantation, Kyoto University Graduate School of Medicine
Toyonari Kubota
Department of Surgery, Division of Hepato-Biliary-Pancreatic Surgery and Transplantation, Kyoto University Graduate School of Medicine
Hirofumi Hirao
Department of Surgery, Division of Hepato-Biliary-Pancreatic Surgery and Transplantation, Kyoto University Graduate School of Medicine
Shoichi Kageyama
Department of Surgery, Division of Hepato-Biliary-Pancreatic Surgery and Transplantation, Kyoto University Graduate School of Medicine
Hirokazu Tanaka
Department of Surgery, Division of Hepato-Biliary-Pancreatic Surgery and Transplantation, Kyoto University Graduate School of Medicine
Shinji Uemoto
Department of Surgery, Division of Hepato-Biliary-Pancreatic Surgery and Transplantation, Kyoto University Graduate School of Medicine

Keywords: Extended-Criteria Donor(ECD), Machine Perfusion Preservation, Static Cold Storage, Ischemia/Reperfusion Injury, Donation after cardiac death(DCD), Steatotic liver

JOURNAL FREE ACCESS

2017 Volume 24 Issue 2 Pages 181-187

DOI https://doi.org/10.11378/organbio.24.181

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Abstract

Due to worldwide critical shortage of donor organs, extended-criteria donors (ECD) have been attracting much attention for organ transplantation. Here we describe brief summary of various strategies to utilize ECD organs, and introduce our recent research progresses targeting for functional restoration or maintenance of ECD livers.

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