Exploration of molecular markers for acute rejection in kidney transplantation by metabolome approach

Abstract

The early and accurate diagnosis of rejection after renal transplantation is required for the well-being of recipients. To develop minimally invasive diagnosis the wide variety of novel biomarkers has been evaluated in biofluids such as blood and urea, using metabolomics that performs simultaneous identification and quantification of hundreds of metabolites. Here, we reviewed the recent researches to explore the biomarkers applicable for the diagnosis of rejection after renal transplantation.