Development of transplantable porcine liver graft using organ scaffold and regenerative medicine approach

Abstract

Recent progress of iPS cell technology is one of the promising avenues for organ replacement therapy. Decellularized tissue have been applied to achieve a more complex level of tissue organizations with some success in animal models. If decellularization technology can provide complex liver construction and function as well as niche for the large amount of hepatic cells to replace its metabolic utility, liver regenerative therapy will be realistic. In this review, we focus on organ decellularization as a new regenerative medicine approach, most recently for whole organs, that may be applied in the field of iPS cell therapy.