Liquid Biopsy - Donor-derived Cell-free DNA - in Organ Transplantation

Abstract

The long-term maintenance of graft function following organ transplantation is a crucial issue for future consideration. Recently, donor-derived cell-free DNA has emerged as a non-invasive and sensitive serum biomarker for monitoring graft failure. Its effectiveness in early diagnosis of acute rejection, evaluating therapeutic efficacy, reducing invasive diagnostic procedures, and facilitating safe outpatient monitoring has been well-established. Moreover, it is expected to enhance long-term graft survival when used in conjunction with conventional biomarkers.