WHAT WAS CLARIFIED FROM A FUNCTION ANALYSIS OF THE HUMAN NASAL MUCOSA?

Abstract

Analysis of the mucosal barrier function using a primary culture system of human nasal mucosal epithelium is important to establish a methodology of inflammation control by the transnasal drug delivery route. Tight junctions are one of the important factors contributing to the permeability of the nasal mucosa to drugs, and it is important to study the factors regulating the nasal mucosal permeability to drugs. Furthermore, examination of the immunocompetence of an individual by sampling cells such as dendritic cells and M cells may be expected to contribute to the establishment of immunotherapy for allergic rhinitis or upper respiratory infections using the transnasal approach. In addition, tight junctions are also known as one of the viral receptors, and it is important for the future to study the characteristics of tight junctions to develop treatment strategies for the prevention of viral infections.