Abstract
Aerosolized nebulizer therapy is an ideal drug delivery system (DDS) because it can effectively deliver medications directly to the affected area, and is recognized as a useful route of administration of therapy in various fields. We planned a series of researches on the stability of medications used in nebulizer therapies. We comparatively investigated the aerosol characteristics and chemical stability in various nebulization therapies. The mesh-type ultrasonic nebulizer showed high concentrations of each drug emitted from a nebulizer, percent of respirable particles relative to the total number of emitted particles, and the effective index. We would also like to emphasize the fact that suitable nebulizer therapy can be provided to patients, including infants and the elderly, if devices and drug formulations can be improved. This newly nebulizer can effectively deliver medication and maintain its stability. Since the aerosol characteristics are different between ultrasonic nebulizers and jet-nebulizers, the most effective nebulizer for each patient should be selected based on its aerosol characteristics. Furthermore, the Procaterol Hydrochloride inhalation solution was stable to various types of nebulizers, demonstrating that this solution for inhalation can be used for various nebulization therapies. Pharmacists should take responsibility as the health care professionals responsible for providing patient care that ensures optimal medication therapy outcomes, and provide appropriate interventions in aerosol therapy.
