2022 Volume 65 Issue 6 Pages 240-244
Olfactory neuroblastoma is a rare disease, and reports about late complications are scarce. We experienced a case in which meningitis and panhypopituitarism developed in the late period after Proton beam therapy for Olfactory neuroblastoma. Herein, we report our experience with this case in context of the current literature.
A female in her eighties had undergone Endoscopic Sinus Surgery on the right side 10 years ago. She was diagnosed with Olfactory neuroblastoma and had undergone Proton beam therapy. One week ago, she complained of a headache and was treated for acute sinusitis. However, she experienced consciousness disorder four days ago, and was admitted to another hospital with the diagnosis of meningitis. She was treated with an antibacterial agent but her symptom did not improve. Therefore, the patient was transferred to our hospital to undergo Endoscopic Sinus Surgery for a therapeutic diagnosis. Her consciousness quickly improved on postoperative day 1. Moreover, she developed central diabetes insipidus due to panhypopituitarism, which we considered was induced as a side effect of Proton beam therapy. While there are few reports about late complications of Proton beam therapy for Olfactory neuroblastoma, Proton beam therapy has recently been covered by insurance, and we are concerned that the number of late complications of Proton beam therapy will increase. It is necessary to explain the potential complications to patients and observe them for a long time.
