Abstract
According to histopathological studies in animals, the effects of dihydrostreptomycin and INAH administered intrathecally were initially revealed in the peripheral Corti's organ and then extended to more central acoustic elements. There was no close relation between these histopathological findings and the dosage of dihydrostreptomycin and number of intrathecal injections. Experimental animals given INAH Intrathecally sometimes died following an attack of convulsions but there was no particular histopathological finding in the accoustic organ.
Since it is well known clinically that even one intrathecal injection of dihydrostreptomycin may produce deafness, whereas the side-effects of INAII employed intrathecally are reversible, the intrathecal administration of INAH is more desirable than that of dihydrostreptomycin when such a therapeutic methcd is required.
