Abstract
A case of lingual carcinoma occurred in a 81-year-old female who had frequent episode of stomatitis ophthosa is reported.
Local findings, when referred initially to our clinic, were characterized by a leukoplakia on the left side of the tongue showing tumorous changes.
Histopathological diagnosis of the lesion revealed acanthosis of the epithelium.
Small round cell infiltration was seen without any specific changes.
The patient was followed once or twice a month for 6 months, when she complained of local tenderness.
The second biopsy showed carcinoma in situ. The treatment consisted in local radium irradiation and systemic administration of 5-FU, MMC, and endoxan, which showed a favorable effect on the course of the disease.
The author suspected that the sustained local stimulation by a new artificial denture might have caused a chain of changes: leukoplakia acanthosis and carcinoma in situ.
