Abstract
Thirty-three cases of head and neck malignancies were treated with extracts from tuberculosis bacilli (Maruyama-Vaccine, or SSM) at the Department of Otolaryngology, Dokkyo Medical College and the results are reported together with the data on changes in immunoglobulin values.
The head and neck malignacies included 13 cases of cancer, 5 cases of sarcoma, 3 cases of melanoma and one case each of malignant granuloma and mixed tumor.
The data were collected from cases after elapsed periods of more than 6 months following conclusion of the treatment with SSM.
Twelve cases (52.1%) survived 2 to 3 years, and four cases died. The other cases were within one year after conclusion of the treatment. The diseases of the four cases that died during the observation period were malignant mixed tumor of the maxillary sinus, carcinoma of the maxillary sinus, melanoma of the nose and lung cancer. Those cases that survived 2 to 3 years showed positive DNCB skin reaction and an increase in a2-globulin differential and also in IgG level.
