Abstract
We recently encountered a patient with Osier's disease and a patient with systemic lupus erythematosus (SLE) who showed nasal bleeding. The patient with Osler's disease was a 63-year-old female, who exhibited three signs of Osler's disease, i. e., hereditary predisposition, telangiectasia in the cutaneous mucosa and a hemorrhagic tendency. This patient received conservative treatment and surgical correction of the nasal septum. The nasal mucosa of this patient was histologically examined. Light microscopy revealed hyperplasia and dilatation of capillary vessels. By electron microscopy, thinning of endothelial cells, and stratification, hypertrophy and disruption of the basement membrane were observed.
The patient with SLE was a 45-year-old female, who showed hematologic abnormalities (hemolytic anemia and thrombocytopenia), immunologic abnormalities (presence of LE cells and a biological false positive to the syphilis test) and antinuclear antibodies. This patient received transfusion and steroid therapy. She later received steroids, immunosuppressing agents and plasma exchange therapy, resulting in an increase in erythrocytes and platelets.
