ROLE OF THE HISTAMINE RECEPTORS IN THE INHIBITION OF THE HISTAMINE RELEASE.
STIMULATING EXAMINATION WITH H1 AND H2 AGONISTS IN LEUKOCYTES OF SUGI POLLINOSIS PATIENTS
1988 Volume 31 Issue Supplement4 Pages 321-327
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1988 Volume 31 Issue Supplement4 Pages 321-327
The histamine release from the leukocytes of Sugi Pollinosis patients is inhibited by histamine itself.
We examined whether the histamine-induced inhibition of histamine release was brought about by the stimulation of H1 or H2 receptors. 2-methylhistarhine as the H1 agonist and 4-methylhistamine as the H2 agonist were used.
The results are as follows.
1. The percent inhibition of the histamine release due to antigen stimulation by histamine was 69.2±20.5%(mean±SD), and by H1 agonist was 28.0±20.1%, by H2 agonist was 56.1±22.4%,
2. This inhibition was significantly higher in the antigen-induced release than in the natural release.
3. The inhibition effects of H1 agonist against per histamine was 39.2±25.5% and of H2 agonist was 80.4±19.0%.
4. The feedback mechamism of histamine release is almost found upon the stimulation of the H2 receptors, but only in a little part is found upon the stimulation of the H1 receptors.
