THE EFFECT OF OZONE EXPOSURE ON HISTAMINE RELEASE IN THE LUNG AND NOSE IN MICE

Abstract

The effect of exposure to ozone (O₃) on histamine release in lung and nose was investigated in BALB/C mice, W/W^v mice and +/+ mice.
BALB/C mice were continuously exposed to 0.8ppm O₃ for 3 hours, 1 day, 3 days or 7 days. W/W^v mice and +/+ mice were continuously exposed to 0.8ppm O₃ for 7 days.
In BALB/C mice, the increase in weight of the lung was observed in 1 day, 3 days and 7 days exposure to ozone, but no significant change was observed in histamine contents of the lung through all exposure periods.
In +/+ mice which has mast cells, the increased weight of lung were observed, though no significant change was observed in W/W^v mice which defects mast cell.
These results suggest that O₃ exposure has the effect on histamine release which causes the increased weights of lung, though there is no decrease of histamine contents.