Abstract
In order to decrease the loss of medical aerosol drugs, some useful techniques are discussed with the particle deposition efficiency of the drugs. The aerosol generator named SPSU, Synchronized Rectangular Pressure with Spiral-typed Nozzle-Ultrasonic Aerosol Generator, has been proposed to decrease total loss of aerosol drugs for maxillary sinus diseases, because other general equipments would have disadvantages of the total loss about 15.7-76.2% due to longer tubing, unsuitable shape of nasal adaptor, particle deposition in the vessel of generating part, and useless amount of drugs in expiration period.
Judging from the experimental results of measuring partial deposition efficiency in each part of aerosol generator, a new equipment named SPSU-12 modified from SPSU is noticed to improve the total loss of aerosol delivery by using following effective procedures: The length of tubing between aerosol generator and nose adaptor equipped horizontally is 15 cm, the nose adaptor with spairal nozzles consists of two tubings of which sized are same as human nostril in diameter, the shape of cover of the vessel is used as smaller size of spherical one to recirculate the medical drugs into the vessel by decreasing the amount of particle deposition on the wall of vessel, and the aerosol drugs is controlled by leaking the air flow at the buffer tank in SPSU to deliver only at the inspiration period.
