ERYTHROMYCIN INHIBITS Cl^- SECRETION ACROSS HUMAN NASAL GLAND CELLS

Abstract

To study the regulation of ion transport by the human nasal gland (HNG) cells, we developed a system for culturing HNG cells isolated by enzymatic digestion from human nasal polyps. Erythromycin inhibited acetylcholine-induced Cl^- secretion in human nasal gland cells. On the other hand, erythromycin had no effect on ATPinduced Cl-secretion in human nasal epithelial cells. Thus, erythromycin might have the effect on reducing nasal secretion in chronic sinusitis.