Abstract
In this department, conservative treatment for chronic sinusitis, except for chronic sinusitis caused by nasal polypfullness or advanced lesions, consists of administration oflow doses of macrolide (MLs) for 2-3 months, followedby either surgery or continuation of the conservative therapy, judging by the improvement in symptoms. Since themechanism of action of long term low dose administrationhas not yet been deduced, administration of new quinolone (NQ) can also be considered as an intense supplementaltreatment, if the above treatment does not show any effect.Moreover, the therapeutic effect of NQ manifest within ashort period and its indication for more severe cases, areconsidered important subjects of future research in conservativetherapy. In this study, we have investigated theclinical application of short term administration of NQ athigh dosage and the concurrent use of NQ and MLs in thetreatment of chronic sinusitis.
(1) In the study of the short term, high dosage administrationof NQ, LVFX was given to seven patientswith chronic sinusitis for 7-14 days at a dose of 600mg/day. The clinical efficacy was 57%.
(2) In the study of the coadministration of NQ+ MLs, acombination of LVFX 100-200 mg with RXM 150mg or CAM 200 mg was given daily for 2-4 months.The clinical efficacy was 100%.
No appreciable adverse reactions were observed in both cases. Based on these results, treatment with these antibiotics is considered effective as a conservative therapy for chronic sinusitis. Also, these antibiotics are considered an extension of the long term, low dose conservative therapy of MLs, indicated for the treatment of severe cases and to shorten therapy.
