Abstract
We investigated the effects of a topical application of oxatomide, an antiallergic agent, on allergic rhinitis attacks in actively sensitized guinea pigs. The topical application of an oxatomide nasal spray (0.025%) reduced the severity of allergic rhinitis, which was assessed by determining the leakage of dye and the release of histamine from the nasal cavities of guinea pigs. Furthermore, the oxatomide nasal spray treatment prevented an increase in dye leakage when guinea pigs and rats were treated with histamine. These results indicate that the topical application of oxatomide inhibits both the release and the action of histamine. Therefore, nasal sprays containing anti-allergics drugs may be beneficial for the treatment of allergic rhinitis.
