Abstract
Antibiotics and steroid are used for aerosol therapy in chronic sinusitis. We evaluated aerosol depositions in maxillary and ethomoidal sinuses in 6 patients undergoing endoscopic sinus surgery with 1% cefmenoxime hydrochloride administered by nebulization. More aerosolized particles were deposited in the anterior tip of inferior turbinates, the maxillary sinus, and the posterior ethmoidal cells, in this order. We cultured epithelial nasal polyp cells from a chronic sinusitis patient to dentermine whether dexamethasone alters mucin gene expression induced by lipopolysaccharide. RT-PCR analysis showed that MUC 8 mRNA expression induced by lipopolysaccharide was significantly inhibited by dexamethasone administration.
