Abstract
We report two cases of Wegener's granulomatosis negative for C-ANCA. Case 1 : A 56-year-old man reported throat pain and neck lymphadenopathy. Faucial tonsil, the nasal cavity, and lungs showed a mass-related lesion. Repeated biopsy and pathological findings were negative, however, as was the ANCA test. We diagnosed it as Wegener's granulomatosis suspect. Case 2 : A 67-year-old man reported ophthalmalgia and decreased visual acuity. At first we suspected nasal optic neuropathy, but symptoms did not bear this out. To achieve a definitive diagnosis, we conducted ESS. The histopathological appearance of tissue showed typical findings of Wegener's glanulomatosis. The ANCA test was negative. In negative ANCA findings, histopathology examination is very important in correctly diagnosing Wegener's granulomatosis.
