Abstract
By means of comparing the histopathological changes of the mucous membrane in the nasoparanasal cavities between germ free animals and and ordinary animals, a study was made to find the entity of the function of the nasoparanasal mucous membrane, The results indicated the followings:
1. A definite reduction in weight of the mesenteric lymphnodes was observed in germ free animals.
2. The gnotobid animals revealed negative agglutination titer for Proteus mirabilis, The titer for serum r-globulin was found to be one half of the contrast group.
3. In gnotobid animals, the histopathological findings indicated a pronounced tendency of epithelium to remain monolayer associated with a deminishing evidence of hyalinization.
4. A depressed formation of the secondary lymphnodules has been noticed in germ free animals.
The author concluded that the postnatal morphlogical changes of the nasoparanasal mucous membrane is not created only by passive resistance to the pathogenic microorganisms but also by an active reaction to the bacteria, where the regional changes of the mucous membrane is the result of duplicated effect, one is the regional reaction to the microorganisms and the other is the rebound effect of systemic reaction on the mucous membrane.
