Abstract
It is known that chronic otitis media due to ANCA (antineutrophil cytoplasmic antibody)-associated vasculitis. This study consisted of 32 patients with otitis media with ANCA-associated vasculitis (OMAAV). All patients complained initially ear symptoms such as hearing loss, ear pain and/or otorrhea, which were not improved by treatments with antibiotics and tympanic tube. At the initial visit, granulomatous lesions in tympanic cavity and/or mastoid cavity were seen in all patients. Serum PR3- or MPO-ANCAs were detected in 25 (78%) patients. Thirty (94%) patients had rapid progression of sensory hearing loss. Facial nerve palsy, hypertrophic pachymeningitis and lung/kidney lesions developed in 14 (44%), 8 (25%) and 10 (31%) patients, respectively. Two (6%) patients died because of subarachnoid hemorrhage due to vasculitis of basial artery. We proposed the diagnostic criteria of OMAAV from these findings.
